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Atherosclerosis 129 , 149157 (1997)

Peer review Peer review information Nature Medicine thanks George Bray, Amanda Adler, Victor Volovici and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

Potential Long-Term Risks Although AOD-9604 does not increase IGF-1 levels, there are concerns about its long-term metabolic effects, including: Unknown impact on fat metabolism regulation Since AOD-9604 alters fat-burning pathways, researchers are still investigating whether prolonged use could affect natural fat metabolism

No upstream kinases were predicted for vincristine on its own